KNÚ Anti-Aging Tri-Complex™ was specially formulated by our scientists to contain three of the best anti-aging  ingredients on the market.  Every natural ingredient is strenuously tested by our lab as well as outside labs to ensure that our KNÚ Anti-Aging Tri-Complex™

is composed of only the best ingredients. Our labs have tested the compatibility of each anti aging ingredient to ensure that they all work together to give you the best results possible!

Our unbelievable anti-aging cream is what we like to call the “triple-threat” to age.

KNÚ Anti-Aging Tri-Complex™ heals, smooths, and adds volume to your skin.

Matrixyl
Matrixyl is an amino peptide complex proven to produce dramatic changes in the appearance of the skin. Matrixyl works to reduce the size and depth of lines and wrinkles while reducing free radical and sun damage. The amino acids trigger an increase in elastin and collagen levels to improve the wrinkle volume and skin texture.

A French Study was presented at the 2002 World Congress of Dermatology with astounding results. The women in the study saw a difference in their skin.
The differences were recorded by Doctors:

- 50% decrease in wrinkle depth
- 68% decrease in wrinkle density
- 24% decrease in wrinkle volume

We have an 8% concentration of Matrixyl in our cream. More than any other company in the United States.

Research: http://miracleofyouth.com/matrixyl.pdf

How to Overcome the Appearance of Wrinkles

DNA plays critical role in rejuvenating aging skin. by Verretta Deorosan, M.D.

A graduate of UCLA School of Medicine, Dr. Verretta Deorosan is board certified by the American Board of Internal Medicine. She is a primary care physician with two practices in Los Angeles, California. Her emphasis is on adult and geriatric medicine with a broad-spectrum alternative/complementary approach.

A new understanding of what causes skin aging, plus the development of substances that inhibit or mitigate premature skin aging, can result in profound changes in the appearance of mature skin.

Aging gives and takes away: It gives our skin unwanted free radical damage, and it takes away healthy collagen, making skin stiff and inflexible and causing wrinkled, dried-out skin. But now, researchers can offer new ingredients to help change this look. One of the most promising of these “cosmeceutical” ingredients is called Matrixyl®. Indeed, the results of early research on its stunning effects on wrinkled skin caused a stir at the 20th World Congress of Dermatology in Paris (Matrixyl® 1999).

Significant, Progressive Changes

A six-month study revealed that Matrixyl® temporarily produces “a highly significant reduction in the deep and moderate wrinkles,” the researchers determined. In fact, they documented changes as high as 68% (Matrixyl® 1999). The research left no doubt: Women who had used Matrixyl® throughout the study experienced dramatic results. Plus the longer they used it, the better they looked.

>Figure 1 > © Copyright Laboratoires Sérobiologiques	>Figure 2 > © Copyright Laboratoires Sérobiologiques
The epidermis (outer skin layer) of a 49-year-old woman after the application of a test cream without Endonucleine™. The faint yellow coloration indicates a sparse concentration of DNA in the skin cells. DNA molecules in the skin diminish with age; this loss is a major cause of lines and wrinkles.	The epidermis of the same woman after the application of the same test cream with Endonucleine™ added. The stronger, more vibrant yellow coloration shows a boost in the amount of healthy DNA in the skin cells. This results in smoother, younger-looking skin.

Matrixyl® came into being through the work of two branches of dermatological research: the search for substances that accelerate recovery from skin wounds and investigations into what causes wrinkles. When skin is wounded, tiny cells called fibroblasts change their characteristics (kind of like changing into their work clothes) and help to repair the damaged tissue and assist in the process of forming new tissue. Part of their job is to manufacture new collagen, an important component of connective tissue.

Fibroblasts never completely lose this ability to create more collagen, even in mature skin. After all, even older people’s wounds heal eventually. But as you grow older, your collagen levels dwindle, and your taut, dewy skin dries out and crinkles. “Wrinkles are nothing more or less than the depletion of collagen in the skin,” according to Robert Garonne, Professor of Cell Biology at Lyon University in France.

Acting Like Old Tissue

Why do skin fibroblasts slow down their collagen production as we get older, even though they can still produce it? Scientists found out why: Fibroblasts in aged tissue start acting old themselves. But—and this is a big but—when they are isolated from aged tissue in the lab and exposed to the same stimulating factors the body uses to kick them into gear, skin fibroblasts once again start producing significant quantities of collagen (Matrixyl® 1999).

With this knowledge, cosmetic scientists started exploring ways to stimulate fibroblasts in living skin on living people, not just in Petri dishes in the laboratory. Using the most advanced cosmetic technology, they developed a five-sided molecule called palmitoyl pentapeptide. This molecular “suitcase” is small enough to be absorbed into skin tissue and uses a delivery system that specifically targets skin cells—providing door-to-door delivery, as it were. The pentapeptide was then loaded with a precious cargo for skin cells: the stimulating factors that get fibroblasts pumping out collagen, plus a unique agent called Endonucleine™ (Laboratoires Serobiologiques 1989).

Skin Needs Hydration

Skin needs water—a great deal of it—to keep its cells plump and saturated with moisture. These moisture-saturated skin cells help your skin look firm and taut. As aging skin dries out and loses its ability to stay hydrated, your skin turns from looking like peaches to prunes.

Endonucleine™ helps skin maintain its hydrating ability by supplying natural and synthetic versions of skin cells’ own genetic material: the nucleic acids DNA and RNA. DNA carries the specific information for the cell, including how to hydrate it, while RNA transmits that information. By reconstituting the skin’s DNA and RNA, Endonucleine™ has a pronounced hydrating and moisturizing effect on the skin.

A Classic Double-Blind Study

Matrixyl® wowed dermatologists at the Paris conference with its demonstrated effects in women. The six-month, double-blind study involved 35 women ages 34 to 72, all of whom had wrinkles (skin experts call it “photodamaged skin”). The researchers set five parameters: global area of wrinkles, density of furrows, volume of wrinkles, mean depth of the main wrinkle, and roughness of skin. Using sophisticated imaging techniques, including photometry and computerized image analysis, they measured these five markers at the beginning of the study and two months, four months, and six months later.

The women were divided into two groups. The first group of 25 women put a cream containing Matrixyl® on one side of the face and a placebo cream on the other. The other 10 put Matrixyl® cream on one side and a commercial vitamin-C cream on the other. None of the women knew which cream contained what.

The researchers reported, “A highly significant reduction in the deep and moderate wrinkles was obtained on the side treated with 3% Matrixyl®. This reduction increased with time, and a difference developed from the placebo, which never produced a significant effect. The surface area occupied by deep wrinkles was reduced by a mean of 68% over six months. The surface area occupied by moderate wrinkles was reduced by a mean of 51% over six months.”

Regarding the density of furrows, the researchers reported, “This parameter takes into account the length of the deepest wrinkles; their total sum relative to the area under analysis is used to define the density per unit area. A very marked reduction in the mean density was found for Matrixyl®, whereas the placebo tended to have the opposite effect. The results produced by Matrixyl® improved with time: -28% after two months, -31% after four months, and -47% after six months.”

Big Changes

The researchers also assessed the volume of wrinkles. To do this, for each subject they selected one of the deepest wrinkles, then measured its changes over time. As to their results, they reported that the volume of the wrinkle “decreased with time, successively being reduced by 7% (two months), 21% (four months), and 24% (six months). The placebo continued to produce no effect.”

Matrixyl® also helped to reduce the roughness of the skin, an effect that became visible after two months (-10%), which intensified with time to reach -16% after six months.”

Concerning the depth of the main wrinkle, they reported, “This determination is useful because it provides a good illustration of the improvement obtained on the most severely affected area of skin. It is therefore a rigorous criterion for evaluating the efficacy of the product. The mean depth of the wrinkle decreased throughout the treatment.”

Self-Evaluation of Female Subjects

The women reported that Matrixyl® “produces lasting moisturizing of the skin,” “makes the skin smoother,” “makes the skin more supple,” and “reduces wrinkles and lines.” These and their own results led the researchers to conclude that their study demonstrates “the long-term anti-wrinkle activity of Matrixyl®. The parameters used to compare the Matrixyl® cream with the placebo cream were significant throughout the treatment. These differences increased with time, which indicates that the physiological activity of the peptide in the skin was progressive.”

There you have it. We now have a golden opportunity to look as good as we feel—and for far longer. After all, many of us have reached another one of those irritating milestones: The clerk no longer asks to see your ID when you buy that bottle of wine. He doesn’t see how young at heart you are. All he sees are the years on your face.

“Don’t deny your age. Defy it!” actress Melanie Griffith urges in a popular TV ad. With Matrixyl® you can defy the premature signs of aging, by reminding your skin cells what they’re supposed to do: stay hydrated and produce collagen. It just took 21st-century technology to figure out how to do it, and now we all can reap the benefits. I can hardly wait to tell my patients.

KGF (Keratinocyte Growth Factor)
KGF is the newest, most potent molecule in the market today. KGF works specifically to increase facial volume. KGF fills creases (especially frown lines) and lifts any sagging on the face (jowls).

Women and Men in their 20’s have a cell turnover rate of about 2-3 weeks and the more we age, the slower the cell turnover rate. KGF speeds up the cell turnover rate by 8 times. More than any other ingredient. It also slows down DNA fragmentation preventing cells from reproducing too rapidly or out of control.

Snail Secretion
Snail Secretion has unbelievable regenerative properties. The fluid that snails secrete protects them from UV radiation, environmental pollutants and free radicals.
Snail Secretion is great for every skin type.

Snail Secretion:
-Helps protect against environmental aggressors
-Opens clogged pores
-Restores tissue plasticity
-Fights teen and adult acne
-Helps reduce scarring (including acne scars)
-Accelerates the renewal of damaged tissues
-Induces quick skin regeneration after wound healing
-Prevents and treats scars and stretch marks
-Fights scalp and skin infections
-Helps avoid keloids and abnormal scars
-Counteracts sun damage preventing premature skin aging and wrinkles

We have an 85% concentration of Snail Secretion in our cream. More than any company in the United States.

Research: http://hubpages.com/hub/skinregeneration